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A callus is an especially toughened area of skin which has become relatively thick and hard as a response to repeated contact or pressure. Since repeated contact is required, calluses are most often found on hands or feet. Calluses are generally not harmful, but may sometimes lead to other problems, such as infection. To treat calluses often times a friction-reducing insole or other material is put into a shoe or against the foot. In some cases, this will reduce the painfulness without actually making the callus go away. Salicylic Acid can also be used in many cases as it decreases keratinocyte adhesion and increases water binding which leads to hydration of the keratin.
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