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Atypical Fibroxanthoma or as it is commonly referred to, AFX, is a tumor that occurs primarily in older individuals after the skin of the head and neck has been damaged significantly by sun exposure and/or therapeutic radiation. Clinically, lesions usually are suggestive of malignancy because they arise rapidly in skin in which other skin cancers have been found and treated. Historically, lesions show a highly atypical and pleomorphic cellular appearance, but they typically respond to simple excision. Cliniopathologic correlation is essential. Factors important to consider are lesion location, patient age, histopathologic appearance, and the observation that the tumor arises from the dermis, not the fat.
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